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© Research
Publication : Lancet (London, England)

Effect of pregnancy on chronic hepatitis C: a case-control study

Team: Archived: Immunobiology of Dendritic Cells
Member:
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Lancet (London, England) - 14 Oct 2000

Fontaine H, Nalpas B, Carnot F, Bréchot C, Pol S

Link to Pubmed [PMID] – 11073028

Lancet 2000 Oct;356(9238):1328-9

There is evidence of deterioration of hepatitis C after pregnancy. To investigate potential histological changes, we compared liver biopsy samples taken before and after delivery from 12 women positive for hepatitis C virus (HCV) and 12 nonpregnant HCV-positive women. Semiquantitative histopathological measurements showed greater deterioration in cases than in controls (necroinflammatory score deterioration 83.3% vs 25.0%; fibrosis score 41.6% vs 8.3%). This case-control study suggests that pregnancy may worsen HCV-related histopathological injury.