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© Research
Publication : Cellular and molecular neurobiology

Early activation of extracellular signal-regulated kinase signaling pathway in the hippocampus is required for short-term memory formation of a fear-motivated learning

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cellular and molecular neurobiology - 01 Jul 2006

Igaz LM, Winograd M, Cammarota M, Izquierdo LA, Alonso M, Izquierdo I, Medina JH

Link to Pubmed [PMID] – 16977492

Cell. Mol. Neurobiol. 2006 Jul-Aug;26(4-6):989-1002

1. According to its duration there are, at least, two major forms of memory in mammals: short term memory (STM) which develops in a few seconds and lasts several hours and long-term memory (LTM) lasting days, weeks and even a lifetime. In contrast to LTM, very little is known about the neural, cellular and molecular requirements for mammalian STM formation. 2. Here we show that early activation of extracellular signal-regulated kinases 1/2 (ERK1/2) in the hippocampus is required for the establishment of STM for a one-trial inhibitory avoidance task in the rat. Immediate posttraining infusion of U0126 (a selective inhibitor of ERK kinase) into the CA1 region of the dorsal hippocampus blocked STM formation. 3. Reversible inactivation of the entorhinal cortex through muscimol infusion produced deficits in STM and a selective and rapid decrease in hippocampal ERK2 activation.4. Together with our previous findings showing a rapid decrease in ERK2 activation and impaired STM after blocking BDNF function, the present results strongly suggest that ERK2 signaling in the hippocampus is a critical step in STM processing.

http://www.ncbi.nlm.nih.gov/pubmed/16977492