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© Biologie structurale et chimie
Structure du domaine en doigt de zinc de la protéine NEMO, déterminée par Résonance magnétique nucléaire (RMN). Cette protéine jouant un rôle dans des maladies (cancer, inflammation), les connaissances acquises sur sa structure offrent de précieuses informations sur sa fonction.
Publication : Chemical communications (Cambridge, England)

Dye-functionalized phosphate-binding macrocycles: from nucleotide to G-quadruplex recognition and “turn-on” fluorescence sensing.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Chemical communications (Cambridge, England) - 28 Sep 2021

Oshchepkov AS, Reznichenko O, Xu D, Morozov BS, Granzhan A, Kataev EA,

Link to Pubmed [PMID] – 34581337

Link to DOI – 10.1039/d1cc04096k

Chem Commun (Camb) 2021 Sep; ():

A novel strategy to design “turn-on” fluorescent receptors for G-quadruplexes of DNA is presented, which relies on the connection of phosphate binding macrocycles (PBM) with naphthalimide dyes. A new PBM-dye family was synthesized and evaluated in terms of binding and detection of nucleotides and DNA G-quadruplexes of different topologies.