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© Research
Publication : European journal of immunology

Does positive selection determine the B cell repertoire?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European journal of immunology - 01 May 1997

Hachemi-Rachedi S, Cumano A, Drapier AM, Cazenave PA, Sanchez P

Link to Pubmed [PMID] – 9174594

Eur. J. Immunol. 1997 May;27(5):1069-74

To know whether each newly formed B cell has an equal chance of survival in the organism, we analyzed the composition of the B cell repertoire of extremely limited diversity by generating mu-transgenic kappa-knockout mice. Surprisingly, in both types of mice studied, the B cell repertoire is mainly composed of cells expressing the mu-transgene-encoded chain associated with only one out four available lambda types depending on the mu transgene. Moreover, B cell differentiation cultures in vitro show that newly formed B cells can express the various lambda types regardless of the presence or absence of the mu transgenes. These results show a drastic impact of the heavy chain on the lambda light chain repertoire expressed in the periphery. The overexpression of a unique heavy/light chain pairing therefore results from selective processes. The immature B cells may be positively selected to provide the immunocompetent B cells in the periphery.

http://www.ncbi.nlm.nih.gov/pubmed/9174594