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© Research
Publication : Infection and immunity

Do kinetics of the humoral response to Cryptococcus neoformans proteins during murine cryptococcosis reflect outcome?

Member: Françoise Dromer
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Infection and immunity - 01 Jun 2000

Neuville S, Lortholary O, Dromer F

Link to Pubmed [PMID] – 10816535

Infect. Immun. 2000 Jun;68(6):3724-6

The kinetics of the humoral response to Cryptococcus neoformans proteins were studied in outbred mice infected with isolate NIH52D. Future nonsurvivors had earlier and stronger (i.e., more bands recognized) humoral responses than survivors. In addition, antibodies to a 56- to 60-kDa membrane antigen and to a 39- to 40-kDa cytosolic antigen were detected more frequently in samples from future nonsurvivors and from survivors, respectively (P < 0.05).