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© Research
Publication : Comptes rendus biologies

Differential roles of auditory and visual cortex for sensory detection in mice.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Comptes rendus biologies - 11 May 2022

Ceballo S, Deneux T, Siliceo M, Bathellier B,

Link to Pubmed [PMID] – 35787621

Link to DOI – 10.5802/crbiol.72

C R Biol 2022 May; 345(1): 75-89

Sensory cortex encompasses the regions of the cerebral cortex that receive primary sensory inputs and is crucial for conscious sensory perception in humans. Yet, some forms of perception are possible without sensory cortex. For example in animal models, the association of a sound detection to a simple behavior resists to the inactivation of auditory cortex. In contrast, post-training inactivation experiments conducted in visual or somatosensory cortex led to much stronger effects. Here we show that muscimol inactivation of visual or auditory cortex in the same detection protocol transiently abolishes visual but not auditory detection. We also observe that cortex-dependency correlates with longer reaction times. This suggests that auditory cortex is more easily bypassed by other circuits for stimulus detection than other primary sensory areas, which may be due to timing differences between auditory and visual associations.Le cortex sensoriel englobe les régions du cortex cérébral qui reçoivent les entrées sensorielles primaires et il est crucial pour la perception sensorielle consciente chez les humains. Pourtant, certaines formes de perception sont possibles sans cortex sensoriel. Par exemple, chez des modèles animaux, l’association d’une détection sonore à un comportement simple résiste à l’inactivation du cortex auditif. En revanche, des expériences d’inactivation post-entraînement menées dans le cortex visuel ou somatosensoriel ont conduit à des effets beaucoup plus forts. Nous montrons ici que l’inactivation par le muscimol du cortex visuel ou auditif dans le même protocole de détection abolit transitoirement la détection visuelle mais pas la détection auditive. Nous observons également que la dépendance au cortex est corrélée à des temps de réaction plus longs. Cela suggère que le cortex auditif est plus facilement contourné par d’autres circuits pour la détection des stimuli que d’autres zones sensorielles primaires, ce qui peut être dû à des différences de timing entre les associations auditives et visuelles.