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© Shalin E. Abraham, Michael Häusser, Christoph Schmidt-Hieber, University College London
The dentate gyrus is one of the few mammalian brain regions where new neurons are generated throughout life. The image was taken with a confocal microscope from a parasagittal slice of the mouse hippocampus. Cells were labelled with fluorescent markers: Newly generated neurons are red (doublecortin), mature neurons are green (NeuN), and nuclei are blue (DAPI)
Publication : Neuron

Differential Relation between Neuronal and Behavioral Discrimination during Hippocampal Memory Encoding.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Neuron - 09 Oct 2020

Allegra M, Posani L, Gómez-Ocádiz R, Schmidt-Hieber C,

Link to Pubmed [PMID] – 33068531

Link to DOI [DOI] – S0896-6273(20)30756-X10.1016/j.neuron.2020.09.032

Neuron 2020 Oct; ():

How are distinct memories formed and used for behavior? To relate neuronal and behavioral discrimination during memory formation, we use in vivo 2-photon Ca2+ imaging and whole-cell recordings from hippocampal subregions in head-fixed mice performing a spatial virtual reality task. We find that subthreshold activity as well as population codes of dentate gyrus neurons robustly discriminate across different spatial environments, whereas neuronal remapping in CA1 depends on the degree of difference between visual cues. Moreover, neuronal discrimination in CA1, but not in the dentate gyrus, reflects behavioral performance. Our results suggest that CA1 weights the decorrelated information from the dentate gyrus according to its relevance, producing a map of memory representations that can be used by downstream circuits to guide learning and behavior.

https://pubmed.ncbi.nlm.nih.gov/33068531