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© Research
Publication : Annales de biologie clinique

[Current aspects of bacterial resistance to antibiotics]

Team: Archived: Group : Patrick Trieu-Cuot
Member: Patrick Trieu-Cuot
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Annales de biologie clinique - 01 Jan 1989

Brisson-Noel A, Trieu-Cuot P, Sougakoff W, Courvalin P

Link to Pubmed [PMID] – 2660637

Ann. Biol. Clin. (Paris) 1989;47(2):98-101

New aspects of the evolution of bacterial antibiotic resistance are discussed. Dissemination of antibiotic resistance appears to be unlimited since resistance genes from Gram-positive cocci have been detected in Gram negative bacteria. This suggests the occurrence of heterogramic genetic transfers between these phylogenetically distinct organisms. New characters of resistance to beta-lactam antibiotics in enterobacteria result from the apparition of mutant of the TEM-1 and TEM-2 penicillinases. Mutations that confer the capacity to hydrolyze the third generation cephalosporins are located in the active site of the enzymes.