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© Valérie Choumet
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).
Publication : Transactions of the Royal Society of Tropical Medicine and Hygiene

Current absence of pyrimethamine resistance of Plasmodium falciparum in Madagascar

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Transactions of the Royal Society of Tropical Medicine and Hygiene - 01 Sep 2002

Randrianarivelojosia M, Ariey F, Raharimalala LA, Parzy D, Rogier C, Jambou R

Link to Pubmed [PMID] – 12474489

Trans. R. Soc. Trop. Med. Hyg. 2002 Sep-Oct;96(5):557-9

Reported are (i) the in vitro sensitivities to pyrimethamine of 58 primary Plasmodium falciparum isolates collected from the foothill and coastal areas in Madagascar, and (ii) the results of the amplification of the dhfr gene followed by restriction enzyme digestion of codon 108. Testing took place between March 1999 and February 2000 and all the isolates were sensitive to pyrimethamine. The 50% inhibitory concentration (IC50) ranged from 0.1 nM to 242.9 nM (mean IC50 = 30.5 nM, median IC50 = 4.8 nM, 95% confidence interval 17.6-43.4 nM). None of the 58 isolates yielded digestion products after polymerase chain reaction product treatment with BsrI or ScrFI. The results indicate the absence of the dhfr encoding Asn108 and Thr108 among tested clinical isolates. The sensitivity of P. falciparum to pyrimethamine-based antimalarial drugs in Madagascar is discussed.

http://www.ncbi.nlm.nih.gov/pubmed/12474489