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© Research
Publication : Genome biology

CpG content affects gene silencing in mice: evidence from novel transgenes

Member: Christine Chevalier
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Genome biology - 14 Aug 2003

Chevalier-Mariette C, Henry I, Montfort L, Capgras S, Forlani S, Muschler J, Nicolas JF

Link to Pubmed [PMID] – 12952532

Genome Biol. 2003;4(9):R53

Transgenes are often engineered using regulatory elements from distantly related genomes. Although correct expression patterns are frequently achieved even in transgenic mice, inappropriate expression, especially with promoters of widely expressed genes, has been reported. DNA methylation has been implicated in the aberrant expression, but the mechanism by which the methylation of a CpG-rich sequence can perturb the functioning of a promoter is unknown.