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© Research
Publication : Insect Molecular Biology

cpbAg1 encodes an active carboxypeptidase B expressed in the midgut of Anopheles gambiae

Team: Ecology and Emergence of Arthropod-borne Pathogens
Member: Sarah Bonnet
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Insect Molecular Biology - 01 Apr 2005

C Lavazec, Sarah Bonnet, I Thiery, B Boisson, C Bourgouin

Link to Pubmed [PMID] – 15796749

Link to HAL – pasteur-04008694

Link to DOI – 10.1111/j.1365-2583.2004.00541.x

Insect Molecular Biology, 2005, 14 (2), pp.163 - 174. ⟨10.1111/j.1365-2583.2004.00541.x⟩

We previously used differential display to identify several Anopheles gambiae genes, whose expression in the mosquito midgut was regulated upon ingestion of Plasmodium falciparum. Here, we report the characterization of one of these genes, cpbAg1 , which codes for the first zinc-carboxypeptidase B identified in An. gambiae and in any insect. Expression of cpbAg1 in baculovirus gave rise to an active enzyme, and determination of the N-terminal amino acids confirmed that CPBAg1 contains a signal peptide and a pro-peptide, typical features of digestive zinc carboxypeptidases. cpbAg1 mRNA was mainly produced in the mosquito midgut, where it accumulated in unfed females and was rapidly down-regulated upon blood feeding. Annotation of the An. gambiae genome predicts twentythree sequences coding for zinc-carboxypeptidases of which only two (cpbAg1 and cpbAg2) are expressed at a significant level in the mosquito midgut.