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© Valérie Choumet
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).
Publication : Insect molecular biology

cpbAg1 encodes an active carboxypeptidase B expressed in the midgut of Anopheles gambiae

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Insect molecular biology - 01 Apr 2005

Lavazec C, Bonnet S, Thiery I, Boisson B, Bourgouin C

Link to Pubmed [PMID] – 15796749

Insect Mol. Biol. 2005 Apr;14(2):163-74

We previously used differential display to identify several Anopheles gambiae genes, whose expression in the mosquito midgut was regulated upon ingestion of Plasmodium falciparum. Here, we report the characterization of one of these genes, cpbAg1, which codes for the first zinc-carboxypeptidase B identified in An. gambiae and in any insect. Expression of cpbAg1 in baculovirus gave rise to an active enzyme, and determination of the N-terminal amino acids confirmed that CPBAg1 contains a signal peptide and a pro-peptide, typical features of digestive zinc carboxypeptidases. cpbAg1 mRNA was mainly produced in the mosquito midgut, where it accumulated in unfed females and was rapidly down-regulated upon blood feeding. Annotation of the An. gambiae genome predicts twenty-three sequences coding for zinc-carboxypeptidases of which only two (cpbAg1 and cpbAg2) are expressed at a significant level in the mosquito midgut.

http://www.ncbi.nlm.nih.gov/pubmed/15796749