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© Research
Publication : eLife

Coupling chemosensory array formation and localization.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in eLife - 23 Oct 2017

Alvarado A, Kjær A, Yang W, Mann P, Briegel A, Waldor MK, Ringgaard S

Link to Pubmed [PMID] – 29058677

Link to DOI – 10.7554/eLife.31058

Elife 2017 Oct; 6():

Chemotaxis proteins organize into large, highly ordered, chemotactic signaling arrays, which in Vibrio species are found at the cell pole. Proper localization of signaling arrays is mediated by ParP, which tethers arrays to a cell pole anchor, ParC. Here we show that ParP’s C-terminus integrates into the core-unit of signaling arrays through interactions with MCP-proteins and CheA. Its intercalation within core-units stimulates array formation, whereas its N-terminal interaction domain enables polar recruitment of arrays and facilitates its own polar localization. Linkage of these domains within ParP couples array formation and localization and results in controlled array positioning at the cell pole. Notably, ParP’s integration into arrays modifies its own and ParC’s subcellular localization dynamics, promoting their polar retention. ParP serves as a critical nexus that regulates the localization dynamics of its network constituents and drives the localized assembly and stability of the chemotactic machinery, resulting in proper cell pole development.