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© Research
Publication : BMC genomics

Comparative analysis of resistant and susceptible macrophage gene expression response to Leishmania major parasite

Team: Biomics
Member: Béatrice Regnault
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in BMC genomics - 22 Oct 2013

Rabhi I, Rabhi S, Ben-Othman R, Aniba MR, , Trentin B, Piquemal D, Regnault B, Guizani-Tabbane L

Link to Pubmed [PMID] – 24148319

BMC Genomics 2013;14:723

Leishmania are obligated intracellular pathogens that replicate almost exclusively in macrophages. The outcome of infection depends largely on parasite pathogenicity and virulence but also on the activation status and genetic background of macrophages. Animal models are essential for a better understanding of pathogenesis of different microbes including Leishmania.