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© Research
Publication : Cellular microbiology

Coiled-coils in type III secretion systems: structural flexibility, disorder and biological implications

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cellular microbiology - 10 Feb 2009

Gazi AD, Charova SN, Panopoulos NJ, Kokkinidis M

Link to Pubmed [PMID] – 19215225

Cell. Microbiol. 2009 May;11(5):719-29

Recent structural studies and analyses of microbial genomes have consolidated the understanding of the structural and functional versatility of coiled-coil domains in proteins from bacterial type III secretion systems (T3SS). Such domains consist of two or more α-helices forming a bundle structure. The occurrence of coiled-coils in T3SS is considerably higher than the average predicted occurrence in prokaryotic proteomes. T3SS proteins comprising coiled-coil domains are frequently characterized by an increased structural flexibility, which may vary from localized structural disorder to the establishment of molten globule-like state. The propensity for coiled-coil formation and structural disorder are frequently essential requirements for various T3SS functions, including the establishment of protein-protein interaction networks and the polymerization of extracellular components of T3SS appendages. Possible correlations between the frequently observed N-terminal structural disorder of effectors and the T3SS secretion signal are discussed. The results for T3SS are also compared with other Gram-negative secretory systems.

https://www.ncbi.nlm.nih.gov/pubmed/19215225