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© Research
Publication : Microbes and infection

Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon 268 mutations.

Member: Lise Musset
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Microbes and infection - 01 Sep 2006

Musset L, Bouchaud O, Matheron S, Massias L, Le Bras J,

Link to Pubmed [PMID] – 16962361

Link to HAL – Click here

Link to DOI – 10.1093/jac/dki420

Microbes Infect 2006 Sep; 8(11): 2599-604

Plasmodium falciparum resistance to atovaquone-proguanil has so far been associated with Y268S or Y268N mutations in cytochrome b, although these changes were identified in only seven of the 11 treatment failures. Here, we describe 10 new cases of atovaquone-proguanil treatment failures among which the parasite resistance was confirmed in six cases, either by identifying correct plasma drug concentrations or by observing in vitro atovaquone resistance. Resistance was consistently associated with codon 268 mutations (Y268S or a previously unidentified mutation, Y268C). Notably, mutations were not detected before the treatment but only after the drug exposure.