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© Research
Publication : Journal of thoracic disease

Circulating tumor cells (CTCs) for the noninvasive monitoring and personalization of non-small cell lung cancer (NSCLC) therapies.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of thoracic disease - 01 Jan 2019

Pawlikowska P, Faugeroux V, Oulhen M, Aberlenc A, Tayoun T, Pailler E, Farace F

Link to Pubmed [PMID] – 30775027

Link to DOI – 10.21037/jtd.2018.12.80

J Thorac Dis 2019 Jan; 11(Suppl 1): S45-S56

Growing evidences for tumor heterogeneity confirm that single-tumor biopsies frequently fail to reveal the widespread mutagenic profile of tumor. Repeated biopsies are in most cases unfeasible, especially in advanced cancers. We describe here how circulating tumor cells (CTCs) isolated from minimally invasive blood sample might inform us about intratumor heterogeneity, tumor evolution and treatment resistance. We also discuss the advances of CTCs research, most notably in molecularly selected non-small cell lung cancer (NSCLC) patients, highlighting challenges and opportunities related to personalized therapy.