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© Fabrice Chrétien with Ultrapole, colorized by Jean-Marc Panaud
Cellule souche (en jaune) de muscle squelettique partiellement recouverte par la membrane basale, migrant sur une fibre musculaire (en bleu).
Publication : Antimicrobial agents and chemotherapy

Chronic invasive Aspergillus sinusitis and otitis with meningeal extension successfully treated by voriconazole

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 21 Sep 2015

Morgand M, Rammaert B, Poirée S, Bougnoux ME, Tran H, Kania R, Chrétien F, Jouvion G, Lortholary O

Link to Pubmed [PMID] – 26392507

Antimicrob. Agents Chemother. 2015 Sep;

Invasive aspergillosis (IA) is a severe disseminated fungal disease mostly occurring in immunocompromised patients. Yet, central nervous system IA, combining meningitis and skull-base involvement, does not only occur in classical risk-factor group for IA: patients with chronic renal failure and diabetes are also at risk for more chronic forms. In both of our proven IA cases, voriconazole monotherapy was effective without surgery and cerebrospinal fluid and serum 1,3-beta-D-glucan were initially positive, contrary to galactomannan antigen.

http://www.ncbi.nlm.nih.gov/pubmed/26392507