Link to Pubmed [PMID] – 26392507
Antimicrob. Agents Chemother. 2015 Sep;
Invasive aspergillosis (IA) is a severe disseminated fungal disease mostly occurring in immunocompromised patients. Yet, central nervous system IA, combining meningitis and skull-base involvement, does not only occur in classical risk-factor group for IA: patients with chronic renal failure and diabetes are also at risk for more chronic forms. In both of our proven IA cases, voriconazole monotherapy was effective without surgery and cerebrospinal fluid and serum 1,3-beta-D-glucan were initially positive, contrary to galactomannan antigen.