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© Research
Publication : PloS one

Chimeric NP non coding regions between type A and C influenza viruses reveal their role in translation regulation

Team: Archived: Molecular Genetics of RNA Viruses
Member: Sylvie van Der Werf
Member:
Member: Bernadette Crescenzo
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 30 Sep 2014

Crescenzo-Chaigne B, Barbezange C, Frigard V, Poulain D, van der Werf S

Link to Pubmed [PMID] – 25268971

PLoS ONE 2014;9(9):e109046

Exchange of the non coding regions of the NP segment between type A and C influenza viruses was used to demonstrate the importance not only of the proximal panhandle, but also of the initial distal panhandle strength in type specificity. Both elements were found to be compulsory to rescue infectious virus by reverse genetics systems. Interestingly, in type A influenza virus infectious context, the length of the NP segment 5′ NC region once transcribed into mRNA was found to impact its translation, and the level of produced NP protein consequently affected the level of viral genome replication.