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© Research
Publication : Carbohydrate research

Characterization of glucuronic acid containing glycolipid in Aspergillus fumigatus mycelium

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Carbohydrate research - 03 Aug 2009

Fontaine T, Lamarre C, Simenel C, Lambou K, Coddeville B, Delepierre M, Latgé JP

Link to Pubmed [PMID] – 19709651

Carbohydr. Res. 2009 Oct;344(15):1960-7

A glucuronic acid containing glycerolipid was isolated from the filamentous fungi Aspergillus fumigatus. This acidic glycolipid was extracted from the membrane of mycelium and purified by two successive chromatographic steps on DEAE-Sephadex and Silica columns. Chemical structural analysis was performed using methylation, gas-chromatography, gas-chromatography-mass spectrometry, nano-electrospray mass spectrometry and (1)H/(13)C NMR spectra. The corresponding structure is a 3-(O-alpha-glucuronyl)-1,2-diacyl-sn-glycerol, where acyl chains are mainly C(16:0), C(18:0), C(18:1), and C(18:2). This alpha-GlcA-diacylglycerol is not present in fungal conidia. This acidic glycerolipid is described here for the first time in a fungal species. Two homologs of UDP-glucose dehydrogenase that convert UDP-glucose into UDP-glucuronic acid, are present in A. fumigatus genome, UGD1 and UGD2. Gene deletion showed that only UGD1 is essential for the biosynthesis of GlcA-DG. However, no particular phenotype has been observed in the Ugd1Delta mutant. Biological function of this acidic glycolipid remains unknown in A. fumigatus.

http://www.ncbi.nlm.nih.gov/pubmed/19709651