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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.
Publication : Immunodeficiency

Characterization of anergy to the superantigen Staphylococcus enterotoxin B

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Immunodeficiency - 01 Jan 1993

Dannecker G, Schultz H, Mecheri S, Sappler G, Clarke K, Niethammer D, Hoffmann MK

Link to Pubmed [PMID] – 8167688

Immunodeficiency 1993;4(1-4):137-9

In vivo administration of superantigens leads to activation and subsequent depletion or anergy of T cells expressing defined V beta-T cell receptors (TCR). Superantigens have therefore become intensively studied tools for examining parameters of immunoregulation and they may represent model antigens for pathogenic agents. An HIV-encoded superantigen has for example been implicated in the dramatic loss of helper T cells in AIDS. We investigated the response of V beta 8+ T cells in mice after primary and secondary exposure to the superantigen Staphylococcus Enterotoxin B (SEB).

http://www.ncbi.nlm.nih.gov/pubmed/8167688