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© Research
Publication : International journal of molecular sciences

Characterization, Diversity, and Structure-Activity Relationship Study of Lipoamino Acids from sp. and Synthetic Analogues

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in International journal of molecular sciences - 02 Mar 2019

Touré S, Desrat S, Pellissier L, Allard PM, Wolfender JL, Dusfour I, Stien D, Eparvier V

Link to Pubmed [PMID] – 30832353

Int J Mol Sci 2019 Mar;20(5)

A biological evaluation of a library of extracts from entomopathogen strains showed that sp. extract has significant antimicrobial and insecticidal activities. Three hydroxyacyl-phenylalanine derivatives were isolated from this strain. Their structures were elucidated by a comprehensive analysis of their NMR and MS spectroscopic data. The antimicrobial and insecticidal potencies of these compounds were evaluated, and compound showed 67% mortality against larvae at a concentration of 100 ppm, and a minimum inhibitory concentration (MIC) of 16 µg/mL against methicillin-resistant . Subsequently, hydroxyacyl-phenylalanine analogues were synthesized to better understand the structure-activity relationships within this class of compounds. Bioassays highlighted the antimicrobial potential of analogues containing saturated medium-chain fatty acids (12 or 14 carbons), whereas an unsaturated long-chain fatty acid (16 carbons) imparted larvicidal activity. Finally, using a molecular networking-based approach, several close analogues of the isolated and newly synthesized lipoamino acids were discovered in the sp. extract.

https://www.ncbi.nlm.nih.gov/pubmed/30832353