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© Research
Publication : Journal of virology

CCR5 mutations distinguish N-terminal modifications of RANTES (CCL5) with agonist versus antagonist activity

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of virology - 11 Jul 2012

Choi WT, Nedellec R, Coetzer M, Colin P, Lagane B, Offord RE, Hartley O, Mosier DE

Link to Pubmed [PMID] – 22787219

J. Virol. 2012 Sep;86(18):10218-20

CCR5 is the major HIV-1 entry coreceptor. RANTES/CCL5 analogs are more potent inhibitors of infection than native chemokines; one class activates and internalizes CCR5, one neither activates nor internalizes, and a third partially internalizes without activation. Here we show that mutations in CCR5 transmembrane domains differentially impact the activity of these three inhibitor classes, suggesting that the transmembrane region of CCR5, a key interaction site for inhibitors, is a sensitive molecular switch, modulating receptor activity.

http://www.ncbi.nlm.nih.gov/pubmed/22787219