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© Research
Publication : Current opinion in microbiology

Candida albicans biofilms: building a heterogeneous, drug-tolerant environment

Team: Fungal Biology and Pathogenicity
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in microbiology - 06 Apr 2013

Bonhomme J, d'Enfert C

Link to Pubmed [PMID] – 23566895

Curr. Opin. Microbiol. 2013 Aug;16(4):398-403

Fungi are able to form biofilms on medical implants, causing serious infections. A better understanding of fungal biofilm formation is necessary to develop tools for detection or prevention and to identify new antifungal strategies. This review explores recent advances in the characterization at the molecular level of fungal biofilms, especially those formed by the yeast Candida albicans: the identification of complex transcriptional networks that control their formation; the pivotal role of the extracellular matrix in biofilm antifungal tolerance; and the knowledge gained on the physiology of biofilm cells and heterogeneity within these communities. These findings may help develop new, targeted therapeutic strategies.