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© Research
Publication : Annals of internal medicine

Brief communication: case reports of ribavirin treatment for chronic hepatitis E

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Annals of internal medicine - 14 Jun 2010

Mallet V, Nicand E, Sultanik P, Chakvetadze C, Tessé S, Thervet E, Mouthon L, Sogni P, Pol S

Link to Pubmed [PMID] – 20547886

Ann. Intern. Med. 2010 Jul;153(2):85-9

BACKGROUND: There is currently no accepted treatment of chronic hepatitis E virus (HEV) infection.

OBJECTIVE: To report 2 patients in whom ribavirin therapy seemed to alter the natural history of chronic HEV infection.

DESIGN: Case reports.

SETTING: Hepatology unit of a tertiary care center in France.

PATIENTS: A kidney and pancreas transplant recipient and a patient with idiopathic CD4(+) T lymphocytopenia, both with biopsy-proven chronic HEV infection.

INTERVENTION: Patients received oral ribavirin, 12 mg/kg of body weight daily for 12 weeks.

MEASUREMENTS: Liver function tests, detection of HEV RNA (viremia and stool shedding) by reverse transcriptase polymerase chain reaction, and anti-HEV IgM and IgG antibodies.

RESULTS: Both patients had normalized liver function test results after 2 weeks of treatment and cleared HEV after 4 weeks of treatment. Hepatitis E virus RNA remained undetectable in the serum and stools throughout follow-up (3 months and 2 months for the first and second patient, respectively). Side effects were considered mild.

LIMITATION: Given the relatively short follow-up, the achievement of HEV eradication could not be claimed.

CONCLUSION: Ribavirin is a potentially effective treatment of HEV infection and should be evaluated in patients with chronic HEV infection.

PRIMARY FUNDING SOURCE: None.

https://www.ncbi.nlm.nih.gov/pubmed/20547886