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© Research
Publication : Journal of biological regulators and homeostatic agents

BQ-123 inhibits both endothelin 1 and endothelin 3 mediated C6 rat glioma cell proliferation suggesting an atypical endothelin receptor

Team: Archived: Group: Lymphocyte Signaling and Activation
Team: Archived: Lymphocyte Cell Biology
Member: Vincenzo Di Bartolo
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of biological regulators and homeostatic agents - 01 Jul 1993

Sedo , Provero P, Revoltella RP, Di Bartolo V, Beffy P, Mizrahi J

Link to Pubmed [PMID] – 8135146

J. Biol. Regul. Homeost. Agents 1993 Jul-Sep;7(3):95-8

The mitogenic action of endothelins (ETs) 1 and 3 was studied on C6 rat glioma cells in serum-free culture conditions. In order to characterize the ET receptor subtype involved in this effect, BQ-123, and ETA receptor selective antagonist was used. Our results confirmed that both ET-1 and ET-3 are mitogenic peptides for C6 cells and demonstrated for the first time that the ETA receptor antagonist BQ-123 inhibits the proliferative effect of both ET-1 and ET-3 in this cellular system, providing evidence of an atypical ET receptor on C6 cells.