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© Research
Publication : Microbial pathogenesis

Bordetella adenylate cyclase is a virulence associated factor and an immunoprotective antigen

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Microbial pathogenesis - 01 Nov 1989

Guiso N, Rocancourt M, Szatanik M, Alonso JM

Link to Pubmed [PMID] – 2622329

Microb. Pathog. 1989 Nov;7(5):373-80

Bordetella pertussis and Bordetella parapertussis are both causative agents of whooping cough outbreaks. Although not expressing the pertussis toxin, B. parapertussis induces, in a murine model, an acute hemorrhagic edematous alveolitis, similar to that observed with B. pertussis. These data suggest that the pertussis toxin may only play an accessory role in the acute pulmonary syndrome observed during Bordetella infection. Both with B. pertussis and B. parapertussis, the ability to induce lethal pulmonary lesions is associated with enhanced in vitro adenylate cyclase expression and activity. We also demonstrate that passive immunization with specific anti-B. pertussis adenylate cyclase antibodies or active immunization with purified B. pertussis secreted adenylate cyclase protect mice against a lethal respiratory challenge with B. pertussis or B. parapertussis. Our results suggest that adenylate cyclase might be the primary cytotoxin responsible for mouse pulmonary lesions during respiratory tract infection with B. pertussis or with the related species B. parapertussis and is a protective antigen of B. pertussis.

http://www.ncbi.nlm.nih.gov/pubmed/2622329