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© Research
Publication : Nature Medicine

Bone marrow transplantation chemotherapy disrupts regenerative brain cell populations

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature Medicine - 24 Feb 2022

Kurt A. Sailor, Nathalie Cartier

Link to DOI – https://doi.org/10.1038/s41591-022-01722-5

Nat Med (2022). https://doi.org/10.1038/s41591-022-01722-5

Bone marrow transplantation causes peripheral cells to engraft the brain by an unclear mechanism. Microglia, the brain’s immune cells, lose their regenerative capacity when the bone marrow transplantation chemotherapy agent busulfan arrests their cell cycle. This causes a gradual decrease in microglial density, creating a niche for peripheral donor cells to engraft the brain and become resident macrophages.

https://www.nature.com/articles/s41591-022-01722-5