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© Research
Publication : The EMBO journal

Blockade of transgenic gamma delta T cell development in beta 2-microglobulin deficient mice

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The EMBO journal - 01 Jan 1992

Pereira P, Zijlstra M, McMaster J, Loring JM, Jaenisch R, Tonegawa S

Link to Pubmed [PMID] – 1531458

EMBO J. 1992 Jan;11(1):25-31

The gamma delta T cell receptor (TCR) of the hybridoma KN6 recognizes the self molecule encoded by a class I gene which maps within the TL region of the major histocompatibility complex (MHC) of H-2b mice. Mice transgenic (Tg) for this TCR were crossed with mice genetically deficient in beta 2-microglobulin (beta 2m). No mature Tg gamma delta T cells were detected in the thymus or the spleen of the beta 2m- gamma delta Tg mice. We conclude that interaction between the Tg gamma delta TCR and a beta 2m-associated molecule (probably an MHC class I molecule) is required for the generation of mature Tg gamma delta T cells.

http://www.ncbi.nlm.nih.gov/pubmed/1531458