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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.
Publication : Annales de l'Institut Pasteur. Immunology

Biological effect of transferrin on mast cell mediator release during the passive cutaneous anaphylaxis reaction: a possible inhibition mechanism involving iron

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Annales de l'Institut Pasteur. Immunology - 01 Mar 1987

Mécheri S, Peltre G, Lapeyre J, David B

Link to Pubmed [PMID] – 2440461

Ann. Inst. Pasteur Immunol. 1987 Mar-Apr;138(2):213-21

A purification procedure for passive cutaneous anaphylaxis inhibitory factor from BALB/c mouse serum has been previously described. In the present work, this inhibitory activity was found to be related to transferrin. No activity was obtained using iron-unsaturated transferrin, whereas iron-saturated transferrin appeared to be potent. The in vivo inhibition of IgE-dependent mediator release from rat mast cells was also obtained using free iron. This effect was observed when iron was injected prior to or simultaneously with mouse IgE in rat skin. Iron and iron-saturated transferrin could play a role in the mechanism of desensitization by modulating the responsiveness of mast cells.

http://www.ncbi.nlm.nih.gov/pubmed/2440461