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© Research
Publication : Journal of controlled release : official journal of the Controlled Release Society

Bioelectronic cell-based device provides a strategy for the treatment of the experimental model of multiple sclerosis.

Team: Hearing Institute Bioimaging Core Facility
Member: Beatrix Meha
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of controlled release : official journal of the Controlled Release Society - 16 Nov 2022

Audouard E, Michel F, Pierroz V, Kim T, Rousselot L, Gillet-Legrand B, Dufayet-Chauffaut G, Buchmann P, Florea M, Khel A, Altynbekova K, Delgaldo C, Escudero E, Soler ABA, Cartier N, Piguet F, Folcher M,

Link to Pubmed [PMID] – 36370877

Link to DOI – 10.1016/j.jconrel.2022.11.008S0168-3659(22)00752-0

J Control Release 2022 Nov; 352(): 994-1008

Wireless powered optogenetic cell-based implant provides a strategy to deliver subcutaneously therapeutic proteins. Immortalize Human Mesenchymal Stem Cells (hMSC-TERT) expressing the bacteriophytochrome diguanylate cyclase (DGCL) were validated for optogenetic controlled interferon-β delivery (Optoferon cells) in a bioelectronic cell-based implant. Optoferon cells transcriptomic profiling was used to elaborate an in-silico model of the recombinant interferon-β production. Wireless optoelectronic device integration was developed using additive manufacturing and injection molding. Implant cell-based optoelectronic interface manufacturing was established to integrate industrial flexible compact low-resistance screen-printed Near Field Communication (NFC) coil antenna. Optogenetic cell-based implant biocompatibility, and device performances were evaluated in the Experimental Autoimmune Encephalomyelitis (EAE) mouse model of multiple sclerosis.