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  • Director of Center
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© Research
Publication : PLoS pathogens

Azole potentiation in Candida species.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PLoS pathogens - 01 Aug 2023

Stenkiewicz-Witeska JS, Ene IV

Link to Pubmed [PMID] – 37651385

Link to DOI – 10.1371/journal.ppat.1011583

PLoS Pathog 2023 Aug; 19(8): e1011583

Fungal infections are rising, with over 1.5 billion cases and more than 1 million deaths recorded each year. Among these, Candida infections are frequent in at-risk populations and the rapid development of drug resistance and tolerance contributes to their clinical persistence. Few antifungal drugs are available, and their efficacy is declining due to the environmental overuse and the expansion of multidrug-resistant species. One way to prolong their utility is by applying them in combination therapy. Here, we highlight recently described azole potentiators belonging to different categories: natural, repurposed, or novel compounds. We showcase examples of molecules and discuss their identified or proposed mode of action. We also emphasise the challenges in azole potentiator development, compounded by the lack of animal testing, the overreliance on Candida albicans and Candida auris, as well as the limited understanding of compound efficacy.