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© Gail Rozen-Gagnon, Christine Schmitt,
Cells infected with Chikungunya (CHIK) virus.
Publication : Virus research

Arenavirus nucleocapsid protein displays a transcriptional antitermination activity in vivo

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Virus research - 01 Jan 2001

Tortorici MA, Albariño CG, Posik DM, Ghiringhelli PD, Lozano ME, Rivera Pomar R, Romanowski V

Link to Pubmed [PMID] – 11163643

Virus Res. 2001 Jan;73(1):41-55

RNA polymerase pausing and transcriptional antitermination regulates gene activity in several systems. In arenavirus infected cells the switch from transcription to replication is subjected to a hairpin-dependent termination and requires protein synthesis to bypass this signal. The transcriptional antitermination control by Junín virus nucleocapsid protein N, has been demonstrated in vivo by infecting BHK-21 cells expressing this viral protein in the presence of translation inhibitors. This is the first demonstration in vivo of a transcriptional antitermination control in arenavirus-infected cells.

https://www.ncbi.nlm.nih.gov/pubmed/11163643