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© Research
Publication : Biochemical and biophysical research communications

Apoptotic activity of a nuclear form of mitogaligin, a cell death protein

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biochemical and biophysical research communications - 09 Dec 2008

Gonzalez P, Robinet P, Charpentier S, Mollet L, Normand T, Dubois M, Legrand A

Link to Pubmed [PMID] – 19071086

Biochem. Biophys. Res. Commun. 2009 Jan;378(4):816-20

Galig, an internal gene to the galectin-3 gene, encodes two proteins and induces cell death in human cells. Mitogaligin, one of these proteins, contains a mitochondrial targeting sequence and promotes the release of cytochrome c into the cytosol. Here, we show that mitogaligin can also localize to nucleus. The nuclear form of mitogaligin induced cell death through a pathway exhibiting typical properties of apoptosis. These observations indicate for the first time that mitogaligin expresses cytotoxic properties not only when addressed to mitochondria but also when targeted to the nucleus.

http://www.ncbi.nlm.nih.gov/pubmed/19071086