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© Research
Publication : Gastroenterology

APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression

Member: Hafida Fsihi
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Gastroenterology - 16 Aug 2006

Janssen KP, Alberici P, Fsihi H, Gaspar C, Breukel C, Franken P, Rosty C, Abal M, El Marjou F, Smits R, Louvard D, Fodde R, Robine S

Link to Pubmed [PMID] – 17030180

Gastroenterology 2006 Oct;131(4):1096-109

Synchronous activation of the Wnt signaling pathway, mostly because of loss of function of the APC tumor suppressor, and of the oncogenic KRAS-signaling pathway is very frequent in colorectal cancer and is associated with poor prognosis.