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Nursing Staff
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Research Engineer
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Technician
Undergraduate Student
Veterinary
Visiting Scientist

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Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
Director of Department
Director of Institute
Director of National Reference Center
Group Leader
Head of Facility
Head of Operations
Head of Structure
Honorary President of the Departement
Labex Coordinator

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Three families of Asgard archaeal viruses identified in metagenome-assembled genomes

Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editing.

Publication : Journal of pharmacological sciences

Antiviral activity of ciclesonide acetal derivatives blocking SARS-CoV-2 RNA replication.

Team: Insect-Virus Interactions

Member: Shiho Torii

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in Journal of pharmacological sciences - 01 Jul 2022

Tsuji G, Nakajima S, Watashi K, Torii S, Suzuki R, Fukuhara T, Ohoka N, Inoue T, Demizu Y

Link to Pubmed [PMID] – 35641031

Link to DOI – 10.1016/j.jphs.2022.04.001

J Pharmacol Sci 2022 Jul; 149(3): 81-84

Ciclesonide (Cic) is approved as an inhalant for asthma and was clinically tested as a candidate therapy for coronavirus disease 2019 (COVID-19). Its active metabolite Cic2 was recently reported to suppress genomic RNA replication of severe acute respiratory syndrome coronavirus 2. In this study, we designed and synthesized a set of ciclesonide-acetal (Cic-acetal) derivatives. Among designated compounds, some Cic-acetal derivatives with a linear alkyl chain exhibited strong viral copy-number reduction activities compared with Cic2. These compounds might serve as lead compounds for developing novel anti-COVID-19 agents.

Published on: 01 Jul 2022