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© Research
Publication : Trends in parasitology

Antigen presentation by endothelial cells: what role in the pathophysiology of malaria?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in parasitology - 01 Apr 2012

Razakandrainibe R, Pelleau S, Grau GE, Jambou R,

Link to Pubmed [PMID] – 22365903

Link to DOI – 10.1016/j.pt.2012.01.004

Trends Parasitol 2012 Apr; 28(4): 151-60

Disruption of the endothelial cell (EC) barrier leads to pathology via edema and inflammation. During infections, pathogens are known to invade the EC barrier and modulate vascular permeability. However, ECs are semi-professional antigen-presenting cells, triggering T-cell costimulation and specific immune-cell activation. This in turn leads to the release of inflammatory mediators and the destruction of infected cells by effectors such as CD8(+) T-cells. During malaria, transfer of parasite antigens to the EC surface is now established. At the same time, CD8 activation seems to play a major role in cerebral malaria. We summarize here some of the pathways leading to antigen presentation by ECs and address the involvement of these mechanisms in the pathophysiology of cerebral malaria.

https://pubmed.ncbi.nlm.nih.gov/22365903