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© Ottavia Romoli, Institut Pasteur
Visualisation du microbiote par microscopie à fluorescence chez des larves de moustique Ae. aegypti
Publication : Nature communications

Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature communications - 06 Jan 2015

Gendrin M, Rodgers FH, Yerbanga RS, Ouédraogo JB, Basáñez MG, Cohuet A, Christophides GK

Link to Pubmed [PMID] – 25562286

Nat Commun 2015 Jan;6:5921

Malaria reduction is most efficiently achieved by vector control whereby human populations at high risk of contracting and transmitting the disease are protected from mosquito bites. Here, we identify the presence of antibiotics in the blood of malaria-infected people as a new risk of increasing disease transmission. We show that antibiotics in ingested blood enhance the susceptibility of Anopheles gambiae mosquitoes to malaria infection by disturbing their gut microbiota. This effect is confirmed in a semi-natural setting by feeding mosquitoes with blood of children naturally infected with Plasmodium falciparum. Antibiotic exposure additionally increases mosquito survival and fecundity, which are known to augment vectorial capacity. These findings suggest that malaria transmission may be exacerbated in areas of high antibiotic usage, and that regions targeted by mass drug administration programs against communicable diseases may necessitate increased vector control.