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© Research
Publication : Virology

Analysis of variability among endogenous ecotropic MuLV loci in laboratory mice

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Virology - 01 Mar 1993

Nouvel P, Philippe H, Condamine H, Panthier JJ

Link to Pubmed [PMID] – 8382408

Virology 1993 Mar;193(1):450-5

We have isolated a molecular clone of an ecotropic murine leukemia virus from the ovaries of an SWR/J x RF/J hybrid female. The molecularly cloned virus, named pSR3, was demonstrated to induce virus production upon transfection into SWR/J immortalized fibroblasts and to promote germ line integration of proviruses in a fraction of the offspring germline when inoculated to neonate SWR/J females. Sequence analysis reveals that pSR3 is closely related to p623, a plasmid derived from Emv-11 (also referred to as AKV-1). Alignment of the pSR3 sequence with the partial nucleotide sequence of Emv-11 (an endogenous virus carried by BALB/c and C3H/He mice) together with p623 then allows a comparison between three viral sequences. Analysis of these data gives (a) an estimation of the natural divergence rate of MuLV genomes in the course of viral replication (1-5 x 10(-5) mutations per cycle and per nucleotide) and (b) molecular evidence for a recent origin through germ line infection of endogenous loci. From additional clues, Emv-11 appears to be the probable ancestor of at least some of these loci.

http://www.ncbi.nlm.nih.gov/pubmed/8382408