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© Research
Publication : International journal of antimicrobial agents

Analysis of topoisomerase mutations in fluoroquinolone-resistant and -susceptible Campylobacter jejuni strains isolated in Senegal

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in International journal of antimicrobial agents - 16 Jan 2007

Kinana AD, Cardinale E, Bahsoun I, Tall F, Sire JM, Garin B, Boye CS, Dromigny JA, Perrier-Gros-Claude JD

Link to Pubmed [PMID] – 17224260

Int. J. Antimicrob. Agents 2007 Apr;29(4):397-401

In this study, topoisomerase mutations in ciprofloxacin-resistant and -susceptible Campylobacter jejuni were analysed by DNA sequencing. In certain ciprofloxacin-resistant C. jejuni, the mechanism of resistance was complex. The Thr86-Ala substitution in the GyrA protein appears to play a role in increasing the minimum inhibitory concentration of nalidixic acid only. In addition, isolates with this amino acid change and those resistant to quinolones but lacking a mutation in the GyrA quinolone resistance-determining region could be derived from two different clones. Based on gyrA and gyrB polymorphisms, C. jejuni isolates from the Dakar region of Senegal appeared to be less diverse than those from other countries. Moreover, C. jejuni isolates in Senegal appeared to differ from European isolates by lack of a silent mutation at codon 120 of the gyrA gene.

http://www.ncbi.nlm.nih.gov/pubmed/17224260