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© Research
Publication : Journal of natural products

Aedes aegypti Larvicidal Sesquiterpene Alkaloids from Maytenus oblongata

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of natural products - 10 Feb 2017

Touré S, Nirma C, Falkowski M, Dusfour I, Boulogne I, Jahn-Oyac A, Coke M, Azam D, Girod R, Moriou C, Odonne G, Stien D, Houël E, Eparvier V

Link to Pubmed [PMID] – 28186749

J. Nat. Prod. 2017 02;80(2):384-390

Four new sesquiterpene alkaloids (1-4) with a β-dihydroagrofuran skeleton and a new triterpenoid (5) were isolated from an ethyl acetate extract of Maytenus oblongata stems. Their structures were elucidated using 1D and 2D NMR spectroscopy as well as MS and ECD experiments. The M. oblongata stem EtOAc extract and the pure compounds isolated were tested for larvicidal activity against Aedes aegypti under laboratory conditions, and compounds 2 and 3 were found to be active.

https://www.ncbi.nlm.nih.gov/pubmed/28186749