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© Research
Publication : Current opinion in neurobiology

Adult neurogenesis beyond the niche: its potential for driving brain plasticity

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in neurobiology - 29 Dec 2016

Sailor KA, Schinder AF, Lledo PM

Link to Pubmed [PMID] – 28040643

Curr. Opin. Neurobiol. 2017 02;42:111-117

Adult neurogenesis emerges as a tremendous form of plasticity with the continuous addition and loss of neurons in the adult brain. It is unclear how preexisting adult circuits generated during development are capable of modifying existing connections to accommodate the thousands of new synapses formed and exchanged each day. Here we first make parallels with sensory deprivation studies and its ability to induce preexisting non-neurogenic adult circuits to undergo massive reorganization. We then review recent studies that show high structural and synaptic plasticity in circuits directly connected to adult-born neurons. Finally, we propose future directions in the field to decipher how host circuits can accommodate new neuron integration and to determine the impact of adult neurogenesis on global brain plasticity.

https://www.ncbi.nlm.nih.gov/pubmed/28040643