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© Perrine Bomme, Guillaume Duménil, Jean-Marc Panaud.
Coloured scanning electron micrograph (SEM) of Neisseria meningitidis on epithelial cells
Publication : Antimicrobial agents and chemotherapy

Acquisition of Beta-Lactamase by Neisseria meningitidis through Possible Horizontal Gene Transfer.

Team: Invasive Bacterial Infections
Member: Muhamed-Kheir Taha
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 27 Aug 2018

Hong E, Deghmane AE, Taha MK,

Link to Pubmed [PMID] – 29941641

Link to DOI – e00831-1810.1128/AAC.00831-18

Antimicrob Agents Chemother 2018 09; 62(9):

We report the detection in France of a beta-lactamase-producing invasive meningococcal isolate. Whole-genome sequencing of the isolate revealed a ROB-1-type beta-lactamase gene that is frequently encountered in Haemophilus influenzae, suggesting horizontal transfer between isolates of these bacterial species. Beta-lactamases are exceptional in meningococci, with no reports for more than 2 decades. This report is worrying, as the expansion of such isolates may jeopardize the effective treatment against invasive meningococcal disease.