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© Research
Publication : American journal of physiology. Gastrointestinal and liver physiology

Accelerated intestinal transit in inbred mice with an increased number of interstitial cells of Cajal

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in American journal of physiology. Gastrointestinal and liver physiology - 05 Aug 2004

Bellier S, Da Silva NR, Aubin-Houzelstein G, Elbaz C, Vanderwinden JM, Panthier JJ

Link to Pubmed [PMID] – 15297259

Am. J. Physiol. Gastrointest. Liver Physiol. 2005 Jan;288(1):G151-8

The interstitial cells of Cajal (ICC) play an important role in coordinating intestinal motility, and structural alterations in ICC are found in several human digestive diseases. Mouse models with defects in ICC allow a better understanding of their functions. We investigated the pattern of intestinal motility and the distribution of ICC in the PRM/Alf inbred mouse strain, characterized by a selective intestinal lengthening. In PRM/Alf mice, the digestive transit time, evaluated by using thermophilic Bacillus subtilis spores, was normal, indicating accelerated transit. The contractility and slow-wave frequency, recorded on isolated segments from the proximal small intestine, were significantly increased. The number of ICC was also significantly higher along the small intestine and the colon. The concomitant increase of the contractility, the slow-wave frequency, and the number of ICC is consistent with the proposal of a role of ICC number increase in the higher intestinal transit speed. The PRM/Alf model should be useful to further investigate the roles of ICC in the control of digestive motility.

http://www.ncbi.nlm.nih.gov/pubmed/15297259