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© Charles Dauguet
Virus VIH-1 (HIV-1), responsable du sida. Première étape de pénétration dans la cellule. Le virus s'approche du lymphocyte T4 et arrive à proximité de son point d'ancrage le récepteur CD4 qui reconnaît spécifiquement la protéine d'enveloppe virale gp120. On voit nettement le manteau de clathrine qui participe au processus d'endocytose (Grossissement X 190000). Image colorisée.
Publication : Blood

A nonsecreted variant of interleukin-4 is associated with apoptosis: implication for the T helper-2 polarization in HIV infection

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Blood - 19 Dec 2002

Ledru E, Février M, Lecoeur H, Garcia S, Boullier S, Gougeon ML

Link to Pubmed [PMID] – 12515722

Blood 2003 Apr;101(8):3102-5

We report the detection of an interleukin-4 (IL-4) variant whose expression is tightly associated with deprivation apoptosis. It is detected with the 8D4 anti-IL-4 monoclonal antibody (mAb) not only in T helper-2 (Th2) but also in Th1 clones, and primary T cells, and it is a nonsecreted molecule. It is not expressed during primary necrosis. Our data suggest that de novo IL-4 transcription of an alternative IL-4 mRNA (IL-4 delta(13)) is induced during deprivation apoptosis. In HIV-infected patients, increased expression of IL-4 in T cells is highly correlated to increased apoptosis, restricted to 8D4 reactivity (r(2) = 0.84 between % 8D4-8(+) and % 7- amino-actinomycin D-positive [7-AAD(+)] peripheral T cells, P <.0001), and associated with disease progression. The particular reactivity of apoptotic T cells to 8D4 mAb may explain some discordances among studies analyzing the Th1/Th2 balance in HIV infection and questions the function of this intracellular type 2 signal.

http://www.ncbi.nlm.nih.gov/pubmed/12515722