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© Research
Publication : Current Opinion in Neurobiology

A new look at calcium channel α2δ subunits.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current Opinion in Neurobiology - 20 Oct 2010

Claudia S. Bauer; Alexandra Tran-Van-Minh; Ivan Kadurin; Annette C. Dolphin

Link to Pubmed [PMID] – 20579869

Curr Opin Neurobiol. 2010 Oct;20(5):563-71

The classical roles of α(2)δ proteins are as accessory calcium channel subunits, enhancing channel trafficking. They were thought to have type-I transmembrane topology, but we find that they can form GPI-anchored proteins. Moreover α(2)δ-1 and α(2)δ-3 have been shown to have novel functions in synaptogenesis, independent of their effect on calcium channels. In neurons, the α(2)δ-1 subunits are present mainly in presynaptic terminals. Peripheral sensory nerve injury results in the up-regulation of α(2)δ-1 in dorsal root ganglion (DRG) neurons, and there is a consequent increase in trafficking of α(2)δ-1 to their terminals. Furthermore, gabapentinoid drugs, which bind to α(2)δ-1 and α(2)δ-2, not only impair their trafficking, but also affect α(2)δ-1-dependent synaptogenesis. These drugs may interfere with α(2)δ function at several different levels.

http://www.sciencedirect.com/science/article/pii/S0959438810000954