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© Research
Publication : Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology

A new experimental murine aspergillosis model to identify strains of Aspergillus fumigatus with reduced virulence

Team: Archived: Aspergillus
Member:
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology - 01 Jan 2002

Sarfati J, Diaquin M, Debeaupuis JP, Schmidt A, Lecaque D, Beauvais A, Latge JP

Link to Pubmed [PMID] – 12402022

Nihon Ishinkin Gakkai Zasshi 2002;43(4):203-13

Experimental animals are an obligate screen to investigate microorganism pathogenicity. Numerous animal models have been used to analyse the virulence of the opportunistic human pathogen Aspergillus fumigatus but none of the experimental models used previously have been satisfactory. This report discuss these models and presents a murine model of pulmonary aspergillosis that is very easy and the most adapted to compare the pathogenicity of A. fumigatus strains. Strains to be tested are inoculated intranasally and synchronously to mice and strains isolated from the lung of mice killed by the infection are typed. The number of colonies recovered is directly correlated to the virulence of the strain.