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© Mélanie Falord, Tarek Msadek, Jean-Marc Panaud
Staphylococcus aureus "golden staph" in scanning electron microscopy.
Publication : Molecular microbiology

A matter of life and death: cell wall homeostasis and the WalKR (YycGF) essential signal transduction pathway

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Molecular microbiology - 23 Oct 2008

Dubrac S, Bisicchia P, Devine KM, Msadek T

Link to Pubmed [PMID] – 19019149

Mol. Microbiol. 2008 Dec;70(6):1307-22

The WalK/WalR (aka YycG/YycF) two-component system (TCS), originally identified in Bacillus subtilis, is very highly conserved and specific to low G+C Gram-positive bacteria, including a number of important pathogens. An unusual feature is that this system is essential for viability in most of these bacteria. Recent studies have revealed conserved functions for this system, defining this signal transduction pathway as a crucial regulatory system for cell wall metabolism, that we have accordingly renamed WalK/WalR. Here we review the cellular role of the WalK/WalR TCS in different bacterial species, focusing on the function of genes in its regulon, as well as variations in walRK operon structure and the composition of its regulon. We also discuss the nature of its essentiality and the potential type of signal being sensed. The WalK histidine kinase of B. subtilis has been shown to localize to the divisome and we suggest that the WalKR system acts as an information conduit between extracytoplasmic cellular structures and intracellular processes required for their synthesis, playing a vital role in effectively co-ordinating peptidoglycan plasticity with the cell division process.

http://www.ncbi.nlm.nih.gov/pubmed/19019149