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© Research
Publication : Biomolecular NMR assignments

(1)H, (15)N and (13)C resonance assignments and secondary structure prediction of Q4D059, a conserved and kinetoplastid-specific hypothetical protein from Trypanosoma cruzi

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biomolecular NMR assignments - 15 Jul 2014

López-Castilla A, de Menezes RS, D' Andrea ÉD, dos Santos TR, Pires JR

Link to Pubmed [PMID] – 25023139

Biomol NMR Assign 2015 Apr;9(1):161-3

Trypanosoma cruzi is a human parasite that causes Chagas disease, an illness affecting millions of people and without an efficient treatment available. Sequencing the pathogen genome has revealed that near half of protein-coding genes correspond to hypothetical proteins of unknown function, increasing the possibilities for novel target discovery. Q4D059 is a putative essential hypothetical protein from T. cruzi and it is specific and conserved among the trypanosomatid genomes. Here, we report the sequential backbone and side chain resonance assignments and secondary structure analysis of Q4D059, as first step for protein structure determination, function elucidation and drug screening.

http://www.ncbi.nlm.nih.gov/pubmed/25023139