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© Research
Publication : Journal of cell science

Α-arrestins – new players in Notch and GPCR signaling pathways in mammals

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of cell science - 01 Apr 2014

Puca L, Brou C

Link to Pubmed [PMID] – 24687185

J. Cell. Sci. 2014 Apr;127(Pt 7):1359-67

For many years, β-arrestins have been known to be involved in G-protein-coupled receptor (GPCR) desensitization. However, β-arrestins belong to a family of proteins that act as multifunctional scaffolding proteins, in particular during trafficking of transmembrane receptors. The arrestin family comprises visual arrestins, β-arrestins and α-arrestins. In mammals, the functions of the α-arrestins are beginning to be elucidated, and they are described as versatile adaptors that link GPCRs or the Notch receptor to E3 ubiquitin ligases and endocytic factors. These α-arrestins can act in sequence, complementarily or cooperatively with β-arrestins in trafficking and ubiquitylation events. This Commentary will summarize the recent advances in our understanding of the functions and properties of these α-arrestin proteins in comparison to β-arrestins, and will highlight a new hypothesis linking their functional complementarity to their physical interactions. α- and β-arrestins could form transient and versatile heterodimers that form a bridge between cargo and E3 ubiquitin ligases, thus allowing trafficking to proceed.

http://www.ncbi.nlm.nih.gov/pubmed/24687185